Acute Hepatitis-A Virus Infection as a Rare Cause of Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of the mononuclear phagocytic system, characterised by histiocyte and lymphocyte activation. It can be classified as primary secondary HLH. Primary HLH usually presents in childhood, associated with gene mutations. Secondary adulthood, due to an underlying infection, autoimmune disease or malignancy. We describe case acute hepatitis-A virus which was persistent fever, pancytopenia, splenomegaly, hyperferritinemia, hemophagocytosis observed bone marrow. Key Words: lymphohistiocytosis, Hepatitis-A, Mononuclear phagocytes.